FOXO4 is defined as a transcription regulator that inhibits apoptosis in senescent cells by interacting with p53 and promoting the expression of p21cip1, thereby influencing cell cycle arrest and apoptosis pathways.
FOXO4 is at the outset of tumorigenesis
Tumorigenesis is characterized by the aberrant regulation of cell cycle under several stress conditions, including oxidative stress and hypoxia. The mammalian FOXO4 is a pleiotropic transcription factor involved in the regulation of a broad range of cellular pathways that are essential to cell survival. Indeed, under different conditions, the expression and activity of FOXO4 are apparently altered in many cancers.
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